HCID 59805850, compound → HCID 23218604, compound

HRID 1429660Notes

Reaction equation

HRID 1429660 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:7][CH2:8][C:9](=[O:10])[CH2:14][CH2:15]1

Participants

3

Reactant 1

HCID 59805850HCID 59805850, compound

Product 1

HCID 23218604HCID 23218604, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of D3 (7.9 g, 29.4 mmol) in hydrochloric acid (5N, 150 ml) was heated at 50° C. for 2 h. After this period, the reaction mixture was washed with diisopropyl ether (100 ml) and then a saturated solution of sodium hydrogen carbonate (100 ml). The mixture was then extracted with dichloromethane and the extracts dried (MgSO4) and the solvents evaporated in vacuo to give D4 (5.4 g, 82%). C12H13F2NO requires 225; Found 226 (MH+)

Workup

  1. waitAfter this period
  2. washthe reaction mixture was washed with diisopropyl ether (100 ml)
  3. extractionThe mixture was then extracted with dichloromethane
  4. dry with materialthe extracts dried (MgSO4)
  5. customthe solvents evaporated in vacuo

Sources & evidence

ORD record
ord-ccfb022391a645d6a65c2d2295802ece
Source dataset
uspto-grants-2015_01
Patent number
US08940743B2

Reaction notes

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