HCID 67085659, compound → 5-Cyclopropylpyridine-2-carboxylic acid

HRID 1429686Notes

Reaction equation

HRID 1429686 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:10]([O:12]CC3C=CC=CC=3)=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1>CO.[OH-].[OH-].[Pd+2]>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:10]([OH:12])=[O:11])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 67085659HCID 67085659, compound

Product 1

HCID 578277225-Cyclopropylpyridine-2-carboxylic acid

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To a solution of benzyl 5-cyclopropylpicolinate in MeOH (15 mL) was added 20% Pd(OH)2/C (100 mg). The hydrogenolysis with H2 was carried out at room temperature under a H2 balloon. The desired product 5-cyclopropylpicolinic acid (305 mg) was obtained after filtration and concentration.

Workup

  1. customwas carried out at room temperature under a H2

Sources & evidence

ORD record
ord-15671d3ccca24796a7beeb3b8b947cdf
Source dataset
uspto-grants-2015_01
Patent number
US08940748B2

Reaction notes

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