Triethylamine → Ethyl 2-[(3-nitropyridin-2-YL)amino]acetate

HRID 1430048Notes

Reaction equation

HRID 1430048 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl.[NH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(N(CC)CC)C>CCO>[N+:8]([C:7]1[C:2]([NH:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 796132-Chloro-3-nitropyridineHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 14062544Ethyl 2-[(3-nitropyridin-2-YL)amino]acetateYield 74.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-chloro-3-nitropyridine (25.3 g) in EtOH (300 mL) were added ethyl 2-aminoacetate hydrochloride (28.7 g) and triethylamine (28.9 mL) at room temperature, and the mixture was refluxed for 1 day. The mixture was concentrated under reduced pressure. The residual crystals were removed by filtration and washed with AcOEt. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluted with 20%-70% AcOEt in hexane). The residual crystals were removed by filtration and washed with IPE. The filtrate was concentrated under reduced pressure to give the title compound (26.9 g).

Workup

  1. temperaturethe mixture was refluxed for 1 day
  2. concentrationThe mixture was concentrated under reduced pressure
  3. customThe residual crystals were removed by filtration
  4. washwashed with AcOEt
  5. concentrationThe filtrate was concentrated under reduced pressure
  6. customThe residue was purified by column chromatography (silica gel, eluted with 20%-70% AcOEt in hexane)
  7. customThe residual crystals were removed by filtration
  8. washwashed with IPE
  9. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8b0dfb12b6cb4d4a89317eada362bf7c
Source dataset
uspto-grants-2015_01
Patent number
US08940758B2

Reaction notes

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