Ammonia → 2-Pyrrolidinecarboxamide,4-hydroxy-,(2S,4S)-(9CI)

HRID 1430109노트

반응식

HRID 1430109 반응식
Cl.C[O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([OH:11])[CH2:8][NH:7]1)=O.[NH3:12]>CO>[OH:11][C@@H:9]1[CH2:8][NH:7][C@H:6]([C:4]([NH2:12])=[O:3])[CH2:10]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 12764092cis-4-Hydroxy-L-proline methyl ester hydrochloride

생성물 1

HCID 24522602-Pyrrolidinecarboxamide,4-hydroxy-,(2S,4S)-(9CI)

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of (2S,4S)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride (1 g) in a 7M solution of ammonia in methanol (10 ml) is stirred for 18 hours then evaporated and triturated with diethyl ether. The residue is dissolved in the minimum volume of hot methanol and stood at 4° C. for 4 hours. The title compound is isolated by filtration as a white solid.

후처리

  1. customthen evaporated
  2. customtriturated with diethyl ether
  3. dissolutionThe residue is dissolved in the minimum volume of hot methanol

출처 및 근거

ORD 기록
ord-c0cc4f01b0c440edb3099bf48f8ec38c
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940771B2

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