Ammonia → 2-Pyrrolidinecarboxamide,4-hydroxy-,(2S,4S)-(9CI)

HRID 1430109Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1430109
Cl.C[O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([OH:11])[CH2:8][NH:7]1)=O.[NH3:12]>CO>[OH:11][C@@H:9]1[CH2:8][NH:7][C@H:6]([C:4]([NH2:12])=[O:3])[CH2:10]1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 12764092cis-4-Hydroxy-L-proline methyl ester hydrochloride

Produkt 1

HCID 24522602-Pyrrolidinecarboxamide,4-hydroxy-,(2S,4S)-(9CI)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of (2S,4S)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride (1 g) in a 7M solution of ammonia in methanol (10 ml) is stirred for 18 hours then evaporated and triturated with diethyl ether. The residue is dissolved in the minimum volume of hot methanol and stood at 4° C. for 4 hours. The title compound is isolated by filtration as a white solid.

Aufarbeitung

  1. customthen evaporated
  2. customtriturated with diethyl ether
  3. dissolutionThe residue is dissolved in the minimum volume of hot methanol

Quellen und Nachweise

ORD-Eintrag
ord-c0cc4f01b0c440edb3099bf48f8ec38c
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940771B2

Notizen zur Reaktion

Wird geladen…