HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (2S,4S)-4-hydroxypyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | cis-4-Hydroxy-L-proline methyl ester hydrochloride | HCID 12764092 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2S,4S)-4-hydroxypyrrolidine-2-carboxamide | HCID 2452260 | — |
Reaction Steps
A solution of (2S,4S)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride (1 g) in a 7M solution of ammonia in methanol (10 ml) is stirred for 18 hours then evaporated and triturated with diethyl ether. The residue is dissolved in the minimum volume of hot methanol and stood at 4° C. for 4 hours. The title compound is isolated by filtration as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940771B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-c0cc4f01b0c440edb3099bf48f8ec38c |
| Source note | uspto-grants-2015_01 |