反应详情

Phosphorous oxychloride (21.8 ml) and 2-tert.butylpyridin-4-one (2.36 g) is heated at reflux in chloroform (15 ml) for 24 hours and then stood at room temperature for 48 hours before pouring onto ice (100 g). Extraction with CH2Cl2 (3 times 250 ml) is followed by drying of the combined organic layers over magnesium sulphate. Evaporation of the organic layers gives the title compound.

1. additionbefore pouring onto ice (100 g)
2. extractionExtraction with CH2Cl2 (3 times 250 ml)
3. dry with materialby drying of the combined organic layers over magnesium sulphate
4. customEvaporation of the organic layers