N-Iodosuccinimide → N-(5-Iodo-4-methyl-2-thiazolyl)acetamide

HRID 1430118Notes

Reaction equation

HRID 1430118 reaction equation
[I:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[N:11]=[C:12]([NH:15][C:16](=[O:18])[CH3:17])[S:13][CH:14]=1>C(#N)C>[I:1][C:14]1[S:13][C:12]([NH:15][C:16](=[O:18])[CH3:17])=[N:11][C:10]=1[CH3:9]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 280907N-(4-Methylthiazol-2-yl)acetamide

Product 1

HCID 57417074N-(5-Iodo-4-methyl-2-thiazolyl)acetamide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N-Iodosuccinimide (4.75 g) is added portion wise to a solution of N-(4-methyl-thiazol-2-yl)-acetamide (3 g) in acetonitrile (60 ml) at room temperature. After 5 minutes a precipitate forms which is collected by filtration and washed with cold acetonitrile to give the title compound as a white solid.

Workup

  1. filtrationAfter 5 minutes a precipitate forms which is collected by filtration
  2. washwashed with cold acetonitrile

Sources & evidence

ORD record
ord-741d3a2ff74a4adaac463dc967dae66d
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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