Ammonia → HCID 55281684, compound

HRID 1430128Notes

Reaction equation

HRID 1430128 reaction equation
C([O:3][C:4]([C@:6]12[CH2:11][C@H:10]1[CH2:9][CH2:8][NH:7]2)=O)C.[NH3:12]>CO>[C@:6]12([C:4]([NH2:12])=[O:3])[CH2:11][C@H:10]1[CH2:9][CH2:8][NH:7]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66890285HCID 66890285, compound

Product 1

HCID 55281684HCID 55281684, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (1S,5R)-2-aza-bicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester (2.5 g, prepared by the procedure of Hercouet Tetrahedron Assymmetry 1996, 7, 1267-1268.) and 7M ammonia in methanol (20 ml) are heated in a sealed vessel at 80° C. for 5 days. The cooled reaction mixture is evaporated and triturated with hexanes/dichloromethane to give the title compound as a beige solid.

Workup

  1. customprepared by the procedure of Hercouet Tetrahedron Assymmetry 1996, 7, 1267-1268
  2. customThe cooled reaction mixture
  3. customis evaporated
  4. customtriturated with hexanes/dichloromethane

Sources & evidence

ORD record
ord-1edf654c491b4fb8a270b5d36998c255
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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