Ammonia → HCID 55281684, compound

Participants

Reaction Steps

A mixture of (1S,5R)-2-aza-bicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester (2.5 g, prepared by the procedure of Hercouet Tetrahedron Assymmetry 1996, 7, 1267-1268.) and 7M ammonia in methanol (20 ml) are heated in a sealed vessel at 80° C. for 5 days. The cooled reaction mixture is evaporated and triturated with hexanes/dichloromethane to give the title compound as a beige solid.

Provenance & Evidence