Ammonia → HCID 57420321, compound

HRID 1430133Notes

Reaction equation

HRID 1430133 reaction equation
[CH3:1][O:2][CH2:3][C@@:4]12[CH2:16][CH2:15][CH2:14][N:5]1[C@@H](C(Cl)(Cl)Cl)[O:7][C:8]2=O.[NH3:17]>CO>[CH3:1][O:2][CH2:3][C@@:4]1([C:8]([NH2:17])=[O:7])[CH2:16][CH2:15][CH2:14][NH:5]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58092771HCID 58092771, compound

Product 1

HCID 57420321HCID 57420321, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3R,7aR)-7a-methoxymethyl-3-trichloromethyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one (0.6 g) and 7M ammonia in methanol (6 ml) is stood at room temperature for 2 days in a sealed vessel. The reaction mixture is then evaporated to give the title compound as a pale yellow oil which is used without further purification.

Workup

  1. customThe reaction mixture is then evaporated

Sources & evidence

ORD record
ord-fb3f3ee3b8574d7587824541f9cee765
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

Loading…