HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-Cbz-(S)-azetidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | (2S)-Methyl-1-(benzyloxycarbonyl)azetidine-2-carboxylate | HCID 54265762 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Cbz-(S)-azetidine-2-carboxamide | HCID 10823579 | — |
Reaction Steps
A mixture of (S)-azetidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (2.5 g) and 7M ammonia in methanol (10 ml) is stood at room temperature for 18 hours in a sealed vessel. The reaction mixture is then evaporated to give the title compound as a white solid which is used without further purification. MS M+H 235.1 and M−H 233.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940771B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-2f4d7ed15476489cbeda8157be7959af |
| Source note | uspto-grants-2015_01 |