Ammonia → HCID 57420322, compound

HRID 1430136Notes

Reaction equation

HRID 1430136 reaction equation
[F:1][CH:2]([F:16])[C@@:3]12[CH2:15][CH2:14][CH2:13][N:4]1[C@@H](C(Cl)(Cl)Cl)[O:6][C:7]2=O.[NH3:17]>CO>[F:1][CH:2]([F:16])[C@@:3]1([C:7]([NH2:17])=[O:6])[CH2:15][CH2:14][CH2:13][NH:4]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86631914HCID 86631914, compound

Product 1

HCID 57420322HCID 57420322, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (3R,7aS)-7a-difluoromethyl-3-trichloromethyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one (0.19 g) and 7M ammonia in methanol (4 ml) is stood at room temperature for 3 days in a sealed vessel. The reaction mixture is then filtered and evaporated to give the title compound as a pale brown oil which is used without further purification. MS (Method D) M+H 165.

Workup

  1. filtrationThe reaction mixture is then filtered
  2. customevaporated

Sources & evidence

ORD record
ord-b0b1444b071b4f9aa5ae776db66ef5b7
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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