Water → HCID 86631915, compound

HRID 1430138Notes

Reaction equation

HRID 1430138 reaction equation
Br[CH2:2][C:3]([C:5]1[S:9][C:8]([NH:10][C:11](=[O:13])[CH3:12])=[N:7][C:6]=1[CH3:14])=O.[C:15]([NH2:19])(=[S:18])[CH2:16][CH3:17].O>CO.[OH-].[O-2].[P-3].[Mo]>[CH2:16]([C:15]1[S:18][CH:2]=[C:3]([C:5]2[S:9][C:8]([NH:10][C:11](=[O:13])[CH3:12])=[N:7][C:6]=2[CH3:14])[N:19]=1)[CH3:17]

Participants

6

Reactant 3

HCID 962Water2×HCID 2760628PropanethioamideHCID 19974111N-[5-(2-Bromoacetyl)-4-methyl-2-thiazolyl]acetamide

Product 1

HCID 86631915HCID 86631915, compound

Reagents, catalysts & solvents 2

HCID 15935011104-88-4CatalystHCID 887MethanolSolvent

Procedure

N-[5-(2-Bromo-acetyl)-4-methyl-thiazol-2-yl]-acetamide (71.6 mg) (prepared by the procedure of WO 2005/068444) is dissolved in CH3OH (5 mL) at RT, followed by addition of thiopropionamide (21.4 mg) and ammonium phosphomolybdate×H2O (37.5 mg). After completion of the reaction, water is added (25 mL) and the precipitate is filtered off to obtain the title compound as a dark green powder. Title compound: HPLC (Method F) RT 4.86 minutes; MS (Method D) M+H 268.2 and M−H 266.2.

Workup

  1. additionis added (25 mL)
  2. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-5d108beb62124659b7d303129ac809a6
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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