HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86631915, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Propanethioamide | HCID 2760628 | — |
| Reactant | N-[5-(bromoacetyl)-4-methyl-1,3-thiazol-2-yl]acetamide | HCID 19974111 | — |
| Catalyst | Phosphomolybdic acid | HCID 159350 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86631915 | HCID 86631915 | — |
Reaction Steps
N-[5-(2-Bromo-acetyl)-4-methyl-thiazol-2-yl]-acetamide (71.6 mg) (prepared by the procedure of WO 2005/068444) is dissolved in CH3OH (5 mL) at RT, followed by addition of thiopropionamide (21.4 mg) and ammonium phosphomolybdate×H2O (37.5 mg). After completion of the reaction, water is added (25 mL) and the precipitate is filtered off to obtain the title compound as a dark green powder. Title compound: HPLC (Method F) RT 4.86 minutes; MS (Method D) M+H 268.2 and M−H 266.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940771B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-5d108beb62124659b7d303129ac809a6 |
| Source note | uspto-grants-2015_01 |