反应详情

A mixture of 4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-ylamine (Step 40.2) (211 mg, 0.86 mmol) and 1,1′-carbonyldiimidazole (210 mg, 1.3 mmol, 1.5 eq) in DCM (10 mL) is stirred for 14 h at reflux and allowed to cool. The resulting precipitate is collected by filtration to provide 275 mg of the title compound as white solid: ESI-MS: 338.2 [M−H]−.

1. temperatureat reflux
2. temperatureto cool
3. filtrationThe resulting precipitate is collected by filtration