Phthalic Anhydride → HCID 86681297, compound

HRID 1430229Notes

Reaction equation

HRID 1430229 reaction equation
[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([NH2:9])[CH:5]=2)[CH2:3][CH2:2]1.[C:10]1(=O)[O:15][C:13](=[O:14])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]12>O1CCOCC1.CN(C)C=O>[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([N:9]3[C:13](=[O:14])[C:12]4[C:11](=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:10]3=[O:15])[CH:5]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 6811Phthalic AnhydrideHCID 27580143-cyclopropyl-1H-pyrazol-5-amine

Product 1

HCID 86681297HCID 86681297, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

5-Cyclopropyl-1H-pyrazol-3-amine (5 g) was slurried in dioxane (80 mL) and N,N-dimethylformamide (80 mL), then phthalic anhydride (6 g) was added and the reaction was heated at 120° C. for 4 days. The reaction was cooled and concentrated. The crude material was triturated with isopropyl ether/ethanol 1/1 (30 mL) to provide the title compound.

Workup

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated
  3. customThe crude material was triturated with isopropyl ether/ethanol 1/1 (30 mL)

Sources & evidence

ORD record
ord-de714ad554f446b8a559b80210afe499
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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