Pyrazole → HCID 86681304, compound

HRID 1430243Notes

Reaction equation

HRID 1430243 reaction equation
CN(C)[C:3]1[CH:4]=[C:5]([CH2:9]O)[CH:6]=[CH:7][CH:8]=1.[NH:12]1[CH:16]=[CH:15][CH:14]=[N:13]1.[CH3:17]C1(C)C(C)(C)OB(C2C=NNC=2)O1>>[C@@H:8]12[CH2:9][C@@H:5]([CH:6]=[CH:7]1)[CH2:4][C@H:3]2[CH2:17][N:12]1[CH:16]=[CH:15][CH:14]=[N:13]1

Participants

4

Reactant 3

HCID 1048PyrazoleHCID 90133m-(Dimethylamino)benzyl alcoholHCID 27740104-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 1

HCID 86681304HCID 86681304, compound

Procedure

The title compound was prepared by substituting (1R,2R,4R)-bicyclo[2.2.1]hept-5-en-2-ylmethanol for (3-(dimethylamino)phenyl)methanol and pyrazole for 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole in EXAMPLE 34A.

Sources & evidence

ORD record
ord-e5d4b925d95647319ab9476a8a53a6e1
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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