Sodium Hydroxide → HCID 66024353, compound

HRID 1430245Notes

Reaction equation

HRID 1430245 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1([C:12](OC)=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C(OCC)C>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1([CH2:12][OH:13])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 86681305HCID 86681305, compound

Product 1

HCID 66024353HCID 66024353, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Conditions

Temperature
0 °C

Procedure

A solution of EXAMPLE 97A (2.14 g) in diethyl ether (10 mL) was added dropwise to a suspension of LiAlH4 (0.380 g) in diethyl ether (20 mL). Once the addition was finished, the mixture was refluxed for 90 minutes, and then cooled to 0° C. NaOH (2N, aqueous, 50 mL) was then added slowly. The mixture was extracted with ethyl acetate (300 mL) and washed with brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

Workup

  1. additionOnce the addition
  2. temperaturethe mixture was refluxed for 90 minutes
  3. extractionThe mixture was extracted with ethyl acetate (300 mL)
  4. washwashed with brine
  5. dry with materialdried over Na2SO4
  6. filtrationFiltration and evaporation of the solvent

Sources & evidence

ORD record
ord-c8e2ebb8a7aa4b65a1f0e634712296ec
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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