Aluminium lithium hydride → HCID 89498332, compound

HRID 1430278Notes

Reaction equation

HRID 1430278 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:7][CH2:6][CH2:5][C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)([C:8](OCC)=[O:9])[CH2:3]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][C:2]1([CH3:19])[CH2:7][CH2:6][CH2:5][C:4]([CH2:8][OH:9])([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[CH2:3]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 89498130Cyclohexanecarboxylic acid, 3,3-dimethyl-1-(4-morpholinyl)-, ethyl ester

Product 1

HCID 89498332HCID 89498332, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a cooled (0° C.) solution of EXAMPLE 145D (3.7 g) in tetrahydrofuran (20 mL) was added lithium aluminum hydride (720 mg). The cooling bath was removed, and the reaction mixture was stirred at room temperature for 3 hours. The reaction was quenched by the sequential addition of water (0.8 mL) and 15% aqueous NaOH solution (2 mL). The mixture was dried with MgSO4, filtered and concentrated to give the title compound, which was used in the subsequent step without further purification.

Workup

  1. customThe cooling bath was removed
  2. customThe reaction was quenched by the sequential addition of water (0.8 mL) and 15% aqueous NaOH solution (2 mL)
  3. dry with materialThe mixture was dried with MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-471654ea62eb4b6695b7cefb8924e30c
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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