Hydrochloric Acid → HCID 86713633, compound

HRID 1430479Notes

Reaction equation

HRID 1430479 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([NH:15]C(=O)OC(C)(C)C)[CH:12]=[CH:13][CH:14]=2)[CH2:4][CH2:3]1.[ClH:23]>O1CCOCC1>[ClH:23].[ClH:23].[ClH:23].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:12]=[CH:13][CH:14]=2)[NH2:15])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86713634Carbamic acid, N-[3-[(4-methyl-1-piperazinyl)methyl]phenyl]-, 1,1-dimethylethyl ester

Product 1

HCID 86713633HCID 86713633, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl (3-((4-methylpiperazin-1-yl)methyl)phenyl)carbamate (544 mg, 1.781 mmol) in dioxane (10 mL) was treated with HCl (g) for 10 min, then stirred at RT for 3 h. The mixture was concentrated to dryness to afford crude 3-((4-methylpiperazin-1-yl)methyl)aniline trihydrochloride (505 mg, 90% yield) which was used without further purification. MS (ESI) m/z: 306.2 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-d9b13d74713141bb9f28afceb7b613a9
Source dataset
uspto-grants-2015_01
Patent number
US08940756B2

Reaction notes

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