Toluene → HCID 10903687, Verbindung

HRID 1430605Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1430605
[Br:1][C:2]1[C:3](=[O:9])[O:4][CH:5](O)[C:6]=1[Br:7].[C:10]1([CH3:16])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Al+3].[Cl-].[Cl-].[Cl-]>>[Br:1][C:2]1[C:3](=[O:9])[O:4][CH:5]([C:13]2[CH:14]=[CH:15][C:10]([CH3:16])=[CH:11][CH:12]=2)[C:6]=1[Br:7]

Komponenten

4

Edukt 3

HCID 1140TolueneHCID 935593,4-Dibromo-5-hydroxyfuran-2(5H)-oneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 10903687HCID 10903687, Verbindung

Versuchsvorschrift

To a mixture of 3,4-dibromo-5-hydroxyfuran-2(5H)-one (0.5 g, 1.939 mmol) in toluene (5 mL, 1.939 mmol) was added AlCl3 (0.310 g, 2.327 mmol) at room temperature. The mixture was stirred at room temperature overnight. The reaction was quenched with water, extracted with EtOAc (3×20 mL), dried over anhydrous MgSO4, and filtered. The filtrate was concentrated under reduced pressure to give the title compound without further purification. LCMS m/z=332.8 [M+H]+.

Aufarbeitung

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc (3×20 mL)
  3. dry with materialdried over anhydrous MgSO4
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-009bd41cb1684124b03be40af069c937
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940891B2

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