Toluene → HCID 10903687, 화합물

HRID 1430605노트

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HRID 1430605 반응식
[Br:1][C:2]1[C:3](=[O:9])[O:4][CH:5](O)[C:6]=1[Br:7].[C:10]1([CH3:16])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[Al+3].[Cl-].[Cl-].[Cl-]>>[Br:1][C:2]1[C:3](=[O:9])[O:4][CH:5]([C:13]2[CH:14]=[CH:15][C:10]([CH3:16])=[CH:11][CH:12]=2)[C:6]=1[Br:7]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 935593,4-Dibromo-5-hydroxyfuran-2(5H)-oneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 10903687HCID 10903687, 화합물

실험 절차

To a mixture of 3,4-dibromo-5-hydroxyfuran-2(5H)-one (0.5 g, 1.939 mmol) in toluene (5 mL, 1.939 mmol) was added AlCl3 (0.310 g, 2.327 mmol) at room temperature. The mixture was stirred at room temperature overnight. The reaction was quenched with water, extracted with EtOAc (3×20 mL), dried over anhydrous MgSO4, and filtered. The filtrate was concentrated under reduced pressure to give the title compound without further purification. LCMS m/z=332.8 [M+H]+.

후처리

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc (3×20 mL)
  3. dry with materialdried over anhydrous MgSO4
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-009bd41cb1684124b03be40af069c937
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940891B2

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