Potassium Carbonate → 5-(3-Chlorophenyl)-6-p-tolylpyridazin-3(2H)-one

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	(3-Chlorophenyl)boronic acid	HCID 2734323	—
Reactant	5-bromo-6-p-tolylpyridazin-3(2H)-one	HCID 67434410	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	5-(3-Chlorophenyl)-6-p-tolylpyridazin-3(2H)-one	HCID 67434746	57.1%

Reaction Conditions

Temperature	130 °C

Reaction Steps

In a 10 mL heavy-walled sealed tube, a mixture of 5-bromo-6-p-tolylpyridazin-3(2H)-one (0.05 g, 0.189 mmol), 3-chlorophenylboronic acid (0.029 g, 0.189 mmol), Pd(Ph3P)4 (10.90 mg, 9.43 μmol) and K2CO3 (0.283 mL, 0.566 mmol) in dioxane (2 mL) was heated under microwave irradiation at 130° C. for 2 h. The reaction was purified by preparative HPLC to give the title compound (0.032 g). LCMS m/z=297.1 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08940891B2
Source dataset	uspto-grants-2015_01
ORD ID	ord-87804414d21b4f81b9ac372f29c6d7cb
Source note	uspto-grants-2015_01