Ethyl 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine-5-carboxylate → ethyl 4-({3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]phenyl}amino)-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate

HRID 143084Notes

Reaction equation

HRID 143084 reaction equation
[Cl:21][c:22]1[n:23][c:24]([S:34][CH3:35])[n:25][c:26]([CH3:33])[c:27]1[C:28](=[O:29])[O:30][CH2:31][CH3:32].[NH2:1][c:2]1[cH:3][c:4]([CH2:8][CH2:9][N:10]2[C:11](=[O:20])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[C:18]2=[O:19])[cH:5][cH:6][cH:7]1>>[NH:1]([c:2]1[cH:3][c:4]([CH2:8][CH2:9][N:10]2[C:11](=[O:20])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]3[C:18]2=[O:19])[cH:5][cH:6][cH:7]1)[c:22]1[n:23][c:24]([S:34][CH3:35])[n:25][c:26]([CH3:33])[c:27]1[C:28](=[O:29])[O:30][CH2:31][CH3:32]

Participants

3

Reactant 2

HCID 22225416Ethyl 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine-5-carboxylateHCID 672195832-[2-(3-aminophenyl)ethyl]-1H-isoindole-1,3(2H)-dione

Product 1

HCID 58296311ethyl 4-({3-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]phenyl}amino)-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate

Sources & evidence

ORD record
ord-cdd43662a56446698881302907f81fc8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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