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HRID1431228

反应详情

EQUATION

反应方程式

HRID 1431228 的结构方程式

REACTANTS

反应物

2
结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1nccs1
HCID2763259

2-(Tributylstannyl)thiazole

C15H29NSSn

结构：Cc1c(Cl)nc2c(F)cccc2c1Cl
HCID59631031

未命名化合物

PRODUCTS

生成物

1
结构：Cc1c(-c2nccs2)nc2c(F)cccc2c1Cl
HCID59631189

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Prepared according to Procedure E using 2,4-dichloro-8-fluoro-3-methylquinoline (250 mg, 1.087 mmol), 2-tributylstannylthiazole (0.34 mL, 1.087 mmol) and tetrakis(triphenylphosphine)palladium(0) (126 mg, 0.109 mmol) in toluene (4 mL) and heating at reflux overnight. After purification 2-(4-chloro-8-fluoro-3-methylquinolin-2-yl)thiazole was obtained.

WORKUP

后处理

  1. customPrepared
  2. temperatureheating
  3. temperatureat reflux overnight
  4. customAfter purification 2-(4-chloro-8-fluoro-3-methylquinolin-2-yl)thiazole
  5. customwas obtained