HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)-1,3-thiazole → 2-(4-Chloro-8-fluoro-3-methylquinolin-2-yl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)-1,3-thiazole | HCID 2763259 | — |
| Reactant | 2,4-Dichloro-8-fluoro-3-methylquinoline | HCID 59631031 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Chloro-8-fluoro-3-methylquinolin-2-yl)thiazole | HCID 59631189 | — |
Reaction Steps
Prepared according to Procedure E using 2,4-dichloro-8-fluoro-3-methylquinoline (250 mg, 1.087 mmol), 2-tributylstannylthiazole (0.34 mL, 1.087 mmol) and tetrakis(triphenylphosphine)palladium(0) (126 mg, 0.109 mmol) in toluene (4 mL) and heating at reflux overnight. After purification 2-(4-chloro-8-fluoro-3-methylquinolin-2-yl)thiazole was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-19d92524b5a84939b0e34cfac4243f28 |
| Source note | uspto-grants-2015_01 |