反应详情

To a stirred solution of 5-morpholino-3-nitropicolinonitrile (100 mg, 0.43 mmol) in EtOAc (5 mL) was added stannous chloride, dihydrate (0.41 g, 2.13 mmol). The reaction was heated at reflux for 15 min. After this time a white solid precipitates. The suspension was filtered and the resulting solid was washed with 1.0M NaOH (10 mL) and brine (10 mL) and dried under vacuum to give 3-amino-5-morpholinopicolinamide. Mass Spectrum (ESI) m/e=223.2 (M+1).

1. temperatureThe reaction was heated
2. temperatureat reflux for 15 min
3. customAfter this time a white solid precipitates
4. filtrationThe suspension was filtered
5. washthe resulting solid was washed with 1.0M NaOH (10 mL) and brine (10 mL)
6. customdried under vacuum