HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[5-(1,1-Dioxidothiomorpholin-4-yl)-3-nitropyridin-2-yl]morpholine → 5-(1,1-Dioxidothiomorpholin-4-yl)-2-morpholin-4-ylpyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[5-(1,1-Dioxidothiomorpholin-4-yl)-3-nitropyridin-2-yl]morpholine | HCID 59631387 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(1,1-Dioxidothiomorpholin-4-yl)-2-morpholin-4-ylpyridin-3-amine | HCID 59631237 | — |
Reaction Steps
A solution of 4-[5-(1,1-dioxidothiomorpholin-4-yl)-3-nitropyridin-2-yl]morpholine (180 mg, 0.53 mmol) in MeOH (100 mL) was reduced using a continuous flow hydrogenation reactor (flow rate: 1 mL/min, 10% mol Pd/C, temperature 35° C., H2 pressure: 20 bar) to give 5-(1,1-dioxidothiomorpholin-4-yl)-2-morpholin-4-ylpyridin-3-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ee23b3000c54439dad37f47c100cefea |
| Source note | uspto-grants-2015_01 |