Phosphorus oxychloride → 4-Chloro-7-fluoro-2-(2-fluorophenyl)-3-methylquinoline

HRID 1431267노트

반응식

HRID 1431267 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=O.[F:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19](=O)[CH2:20][CH3:21].P(Cl)(Cl)([Cl:25])=O>>[Cl:25][C:4]1[C:3]2[C:2](=[CH:10][C:9]([F:11])=[CH:8][CH:7]=2)[N:1]=[C:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[F:12])[C:20]=1[CH3:21]

참가 물질

4

반응물 3

HCID 24813Phosphorus oxychlorideHCID 5793991-(2-Fluorophenyl)propan-1-oneHCID 27249674-Fluoroanthranilic acid

생성물 1

HCID 596313954-Chloro-7-fluoro-2-(2-fluorophenyl)-3-methylquinoline

실험 절차

Prepared according to Procedure J using 2-amino-4-fluorobenzoic acid (4.90 g, 31.6 mmol) and 1-(2-fluorophenyl)propan-1-one (3.70 g, 24.3 mmol) in phosphorous oxychloride (45.00 mL, 483 mmol) to afford product as a white solid upon purification by chromatography on silica gel. Mass Spectrum (ESI) m/e=290.0 (M+1).

후처리

  1. customPrepared
  2. customto afford product as a white solid
  3. customupon purification by chromatography on silica gel

출처 및 근거

ORD 기록
ord-d89eb9f14c224077870871d3cab0ce4e
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940724B2

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