Phosphorus oxychloride → HCID 59631282, compound

HRID 1431282Notes

Reaction equation

HRID 1431282 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][CH3:10].[NH2:12][C:13]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:14]=1[C:15](O)=O.P(Cl)(Cl)([Cl:25])=O>>[Cl:25][C:15]1[C:14]2[C:13](=[CH:21][C:20]([Cl:22])=[CH:19][CH:18]=2)[N:12]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[C:9]=1[CH3:10]

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 666462-Amino-4-chlorobenzoic acidHCID 5793991-(2-Fluorophenyl)propan-1-one

Product 1

HCID 59631282HCID 59631282, compound

Procedure

Prepared according to Procedure J using 1-(2-fluorophenyl)propan-1-one and 2-amino-4-chlorobenzoic acid in phosphorous oxychloride to afford a colorless solid upon purification by chromatography on silica gel. Mass Spectrum (ESI) m/e=305.9 (M+1).

Workup

  1. customPrepared
  2. customto afford a colorless solid
  3. customupon purification by chromatography on silica gel

Sources & evidence

ORD record
ord-36d90a6d721a4ebeada389f9559233da
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

Loading…