HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anthranilic Acid → 4-Chloro-2-(2-fluorophenyl)-3-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anthranilic Acid | HCID 227 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 1-(2-Fluorophenyl)propan-1-one | HCID 579399 | — |
| Product | 4-Chloro-2-(2-fluorophenyl)-3-methylquinoline | HCID 59631168 | — |
Reaction Steps
Prepared according to Procedure J, using 2-aminobenzoic acid (14.6 g, 106 mmol) and 1-(2-fluorophenyl)propan-1-one (10.78 g, 70.8 mmol) in phosphorous oxychloride (35.00 mL) to afford product as a colorless solid upon purification by chromatography on silica gel, eluting with EtOAc gradient in hexane. Mass Spectrum (ESI) m/e=272.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f5a45899eda243b6ba4cd244387a24ba |
| Source note | uspto-grants-2015_01 |