Diethyl methylmalonate → HCID 67507908, compound

HRID 1431310Notes

Reaction equation

HRID 1431310 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:3]=1[NH2:4].[CH3:10][CH:11]([C:17](OCC)=[O:18])[C:12]([O:14][CH2:15][CH3:16])=[O:13]>>[F:1][C:2]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:3]=1[NH:4][C:17](=[O:18])[CH:11]([CH3:10])[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Participants

3

Reactant 2

HCID 11857Diethyl methylmalonateHCID 677752,5-Difluoroaniline

Product 1

HCID 67507908HCID 67507908, compound

Procedure

Prepared according to Procedure A using 2,5-difluoroaniline (5.00 g, 38.7 mmol) and diethyl 2-methylmalonate to give ethyl 3-(2,5-difluorophenylamino)-2-methyl-3-oxopropanoate. Mass Spectrum (ESI) m/e=258.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bad09df1872f4df09e0254837a235160
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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