2-Methoxy-6-(tributylstannyl)pyridine → 4-Chloro-5,7-difluoro-2-(6-methoxypyridin-2-yl)-3-methylquinoline

HRID 1431315Notes

Reaction equation

HRID 1431315 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Sn](CCCC)(CCCC)CCCC)[N:19]=1>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([O:17][CH3:16])[N:19]=2)[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 105248912-Methoxy-6-(tributylstannyl)pyridineHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 596314824-Chloro-5,7-difluoro-2-(6-methoxypyridin-2-yl)-3-methylquinoline

Procedure

Prepared according to Procedure E using 2,4-dichloro-5,7-difluoro-3-methylquinoline (250 mg, 1.01 mmol) and 2-methoxy-6-(tributylstannyl)pyridine to give 4-chloro-5,7-difluoro-2-(6-methoxypyridin-2-yl)-3-methylquinoline. Mass Spectrum (ESI) m/e=321.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-17e63e8644c34e3da21a7f56d3688195
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

Loading…