2-Piperidone → 1-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one

HRID 1431317Notes

Reaction equation

HRID 1431317 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C:17]1=[O:22]>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C:17]2=[O:22])[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 596315521-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one

Procedure

Prepared according to Procedure I using 2,4-dichloro-5,7-difluoro-3-methylquinoline (250 mg, 1.01 mmol) and piperidin-2-one to give 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one. Mass Spectrum (ESI) m/e=311.0 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a3fdce276f8542a19885881444239e6c
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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