HCID 59631257, compound → HCID 59631399, compound

HRID 1431325Notes

Reaction equation

HRID 1431325 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([O:13]CC)=[O:12])=[CH:4][C:3]=1[F:18]>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([OH:13])=[O:12])=[CH:4][C:3]=1[F:18]

Participants

3

Reactant 1

HCID 59631257HCID 59631257, compound

Product 1

HCID 59631399HCID 59631399, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The acid was prepared according to Procedure B using ethyl 3-(4-chloro-3-fluorophenylamino)-2-methyl-3-oxopropanoate (2.75 g, 10.1 mmol) in THF (10.1 mL) to give 3-(4-chloro-3-fluorophenylamino)-2-methyl-3-oxopropanoic acid. Mass Spectrum (ESI) m/e=245.9 (M+1).

Workup

  1. customThe acid was prepared

Sources & evidence

ORD record
ord-4afaa07b7077405584969b5f077194d9
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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