Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Diethyl methylmalonate | HCID 11857 | — |
| Reactant | 3,5-Difluoroaniline | HCID 96595 | — |
| Product | HCID 59631396 | HCID 59631396 | — |
Reaction Steps
Prepared according to Procedure A using diethyl 2-methylmalonate (34.5 mL, 205 mmol), pyridine (15.6 mL, 190 mmol), and 3,5-difluorobenzenamine (12.4 g, 96 mmol). The reaction was heated to 130° C. for 2 days. Purification afforded ethyl 3-(3,5-difluorophenylamino)-2-methyl-3-oxopropanoate. Mass Spectrum (ESI) m/e=258.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08940724B2 |
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| Source dataset | uspto-grants-2015_01 |
|---|
| ORD ID | ord-f6043931d6094c46a8a80e0c31d98a73 |
|---|
| Source note | uspto-grants-2015_01 |
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