Pyridine → HCID 59631396, compound

HRID 1431392Notes

Reaction equation

HRID 1431392 reaction equation
[CH3:1][CH:2]([C:8]([O:10]CC)=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].N1C=CC=CC=1.[F:19][C:20]1[CH:21]=[C:22]([NH2:27])[CH:23]=[C:24]([F:26])[CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([NH:27][C:8](=[O:10])[CH:2]([CH3:1])[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 11857Diethyl methylmalonateHCID 965953,5-Difluoroaniline

Product 1

HCID 59631396HCID 59631396, compound

Conditions

Temperature
130 °C

Procedure

Prepared according to Procedure A using diethyl 2-methylmalonate (34.5 mL, 205 mmol), pyridine (15.6 mL, 190 mmol), and 3,5-difluorobenzenamine (12.4 g, 96 mmol). The reaction was heated to 130° C. for 2 days. Purification afforded ethyl 3-(3,5-difluorophenylamino)-2-methyl-3-oxopropanoate. Mass Spectrum (ESI) m/e=258.2 (M+1).

Workup

  1. customPrepared
  2. customPurification

Sources & evidence

ORD record
ord-f6043931d6094c46a8a80e0c31d98a73
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

Loading…