2,5-Dimorpholinopyridin-3-amine → 1-(4-((2,5-Di-4-morpholinyl-3-pyridinyl)-amino)-3-ethyl-5,7-difluoro-2-quinolinyl)-2-piperidinone

참여 물질

반응 단계

Prepared according to Procedure H using 1-(4-chloro-3-ethyl-5,7-difluoroquinolin-2-yl)piperidin-2-one (40.0 mg, 0.120 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give 1-(4-((2,5-di-4-morpholinyl-3-pyridinyl)-amino)-3-ethyl-5,7-difluoro-2-quinolinyl)-2-piperidinone. 1H NMR (400 MHz, chloroform-d) δ ppm 7.96 (1H, d, J=11.9 Hz), 7.60 (1H, d, J=2.7 Hz), 7.46 (1H, d, J=9.0 Hz), 6.90-7.07 (1H, m), 6.71 (1H, br. s.), 4.38 (1H, br. s.), 3.85-4.03 (4H, m), 3.71-3.84 (4H, m), 3.58 (1H, d, J=11.0 Hz), 3.34 (2H, ddd, J=11.9, 6.1, 2.9 Hz), 3.08-3.19 (3H, m), 2.92-3.07 (2H, m), 2.43-2.62 (3H, m), 1.92-2.26 (6H, m), 0.97-1.11 (3H, m). Mass Spectrum (ESI) m/e=554.2 (M+1).

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