反应详情

The ester was prepared according to Procedure A using diethyl 2-methylmalonate (7.09 mL, 41.2 mmol), pyridine (4.45 mL, 55.0 mmol) and 2-chloro-5-fluoroaniline (4.0 g, 27.5 mmol) over 6 days. The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes) to give ethyl 3-(2-chloro-5-fluorophenylamino)-2-methyl-3-oxopropanoate as a red oil. Mass Spectrum (ESI) m/e=274.0 (M+1).

1. customThe ester was prepared
2. customThe residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes)