反应详情

The ester was prepared according to Procedure A using diethyl 2-methylmalonate (6.31 mL, 36.7 mmol), pyridine (3.96 mL, 48.9 mmol) and 2-chloro-3,5-difluoroaniline (4.00 g, 24.46 mmol) over 3 days. The residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes) to give ethyl 3-(2-chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoate as a red oil. Mass Spectrum (ESI) m/e=292.0 (M+1).

1. customThe ester was prepared
2. customThe residue was purified by column chromatography on silica gel (0-30% EtOAc/hexanes)