4-Chloro-2-(tributylstannyl)pyridine → HCID 59631059, compound

HRID 1431493Notes

Reaction equation

HRID 1431493 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][N:20]=[C:19]([Sn](CCCC)(CCCC)CCCC)[CH:18]=1>C1(C)C=CC=CC=1>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:19]2[CH:18]=[C:17]([Cl:16])[CH:22]=[CH:21][N:20]=2)[C:11]=1[CH3:12]

Participants

4

Reactant 2

HCID 441182214-Chloro-2-(tributylstannyl)pyridineHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 59631059HCID 59631059, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The Stille coupled product was prepared according to Procedure E using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.5 g, 2.02 mmol), 4-chloro-2-(tributylstannyl)pyridine (0.893 g, 2.22 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol) in toluene (4 mL) to give 4-chloro-2-(4-chloropyridin-2-yl)-5,7-difluoro-3-methylquinoline as a white solid. Mass Spectrum (ESI) m/e=325.0 (M+1).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-ca807cc1a82849babfba1f829bc3c1dc
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

Loading…