HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(tributylstannyl)pyridine → HCID 59631059, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(tributylstannyl)pyridine | HCID 44118221 | — |
| Reactant | 2,4-Dichloro-5,7-difluoro-3-methylquinoline | HCID 59631040 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59631059 | HCID 59631059 | — |
Reaction Steps
The Stille coupled product was prepared according to Procedure E using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.5 g, 2.02 mmol), 4-chloro-2-(tributylstannyl)pyridine (0.893 g, 2.22 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol) in toluene (4 mL) to give 4-chloro-2-(4-chloropyridin-2-yl)-5,7-difluoro-3-methylquinoline as a white solid. Mass Spectrum (ESI) m/e=325.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ca807cc1a82849babfba1f829bc3c1dc |
| Source note | uspto-grants-2015_01 |