Morpholine → 4-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)morpholine

HRID 1431616Notes

Reaction equation

HRID 1431616 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[CH:9][C:10]=2[F:12])[N:5]=[C:4](C2C=CC=CC=2S(C)(=O)=O)[C:3]=1[CH3:24].[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:13])=[CH:9][C:10]=2[F:12])[N:5]=[C:4]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:3]=1[CH3:24]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 596310374-Chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline

Product 1

HCID 596310604-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)morpholine

Procedure

Essentially prepared according to Procedure G using 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline (380.0 mg, 1.50 mmol) and morpholine to give 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)morpholine. Mass Spectrum (ESI) m/e=299.0 (M+1).

Workup

  1. customEssentially prepared

Sources & evidence

ORD record
ord-be764f89e70d4993a8cff576c587117c
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

Loading…