HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2,4-Dichloro-5,7-difluoro-3-methylquinoline | HCID 59631040 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate | HCID 59631055 | — |
Reaction Steps
Essentially prepared according to Procedure G using 2,4-dichloro-5,7-difluoro-3-methylquinoline (610.0 mg, 2.50 mmol) and tert-butyl piperazine-1-carboxylate in isopropanol to give tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-piperazine-1-carboxylate. Mass Spectrum (ESI) m/e=398.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-181d624eaea6462e8a46a3bef88f5c01 |
| Source note | uspto-grants-2015_01 |