2-Fluoro-5-nitrophenylboronic acid, pinacol ester → 4-Chloro-7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methylquinoline

Participants

Reaction Steps

Essentially prepared according to Procedure F using a mixture of 2,4-dichloro-5-fluoro-3-methylquinoline and 2,4-dichloro-7-fluoro-3-methylquinoline (˜1:4 mixture) (690 mg, 3.00 mmol) and 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane to give 4-chloro-7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methylquinoline. Mass Spectrum (ESI) m/e=335.0 (M+1).

Provenance & Evidence