反应详情

The Suzuki coupled product was prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.50 g, 2.02 mmol), 6-(piperidin-1-yl)pyridine-3-boronic acid pinacol ester (0.581 g, 2.02 mmol), palladium tetrakistriphenylphosphine (0.23 g, 0.20 mmol), potassium carbonate (0.56 g, 4.03 mmol) in toluene (4 mL) at 100° C. for 18 h to give 4-chloro-5,7-difluoro-3-methyl-2-(6-(piperidin-1-yl)pyridin-3-yl)quinoline as a yellow solid. Mass Spectrum (ESI) m/e=374.0 (M+1).

1. customwas prepared
2. customat 100° C.
3. customfor 18 h