N-(3-morpholino-5-nitrophenyl)isobutyramide → N-(3-amino-5-morpholinophenyl)isobutyramide

HRID 1431785Notes

Reaction equation

HRID 1431785 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[C:9]([NH:16][C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH:10]=[C:11]([N+:13]([O-])=O)[CH:12]=2)[CH2:3][CH2:2]1>[Pd].CO>[NH2:13][C:11]1[CH:10]=[C:9]([NH:16][C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])[CH:8]=[C:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH:12]=1

Participants

4

Reactant 1

HCID 67507653N-(3-morpholino-5-nitrophenyl)isobutyramide

Product 1

HCID 67507609N-(3-amino-5-morpholinophenyl)isobutyramide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Prepared according to Procedure V by stirring N-(3-morpholino-5-nitrophenyl)-isobutyramide (0.298 g, 1.016 mmol), 10% palladium on carbon (0.216 g, 0.203 mmol), and methanol (3 mL) for 30 minutes to afford N-(3-amino-5-morpholinophenyl)isobutyramide as a beige amorphous solid. Mass Spectrum (ESI) m/e=264.2 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-57f8484e41404b669a02a31655e9e988
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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