1-(3-Aminopropyl)-4-methylpiperazine → HCID 68615734, compound

HRID 1431972Notes

Reaction equation

HRID 1431972 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[CH:15]=[C:14]([CH:16]=O)[CH:13]=[C:12]2[C:18]2[CH:23]=[CH:22][C:21]3[O:24][CH2:25][O:26][C:20]=3[CH:19]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH2:27][CH2:28][CH2:29][CH2:30][N:31]1[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([N:11]2[CH:15]=[C:14]([CH2:16][NH:27][CH2:28][CH2:29][CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)[CH:13]=[C:12]2[C:18]2[CH:23]=[CH:22][C:21]3[O:24][CH2:25][O:26][C:20]=3[CH:19]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 5049666Sodium triacetoxyborohydrideHCID 86611311HCID 86611311, compound

Product 1

HCID 68615734HCID 68615734, compound

Procedure

1-(m-Chlorobenzenesulfonyl)2-(3,4methylenedioxyphenyl)-pyrrole-4-carboxaldehyde and 1-(3-aminopropyl)-4-methylpiperazine are condensed and reduced with NaBH(OAc)3 following the procedure of Example 2. HPLC: RT (program 1) 3.26, MS: 531.0.

Workup

  1. customcondensed
  2. customRT (program 1) 3.26, MS

Sources & evidence

ORD record
ord-e5ec0aa0366549d49afd83bddeed9b01
Source dataset
uspto-grants-2009_11
Patent number
US07612064B2

Reaction notes

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