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温度

0 °C

(S)-5-Hydroxy-5,6,7,8-tetrahydronapthalene-2-carbaldehyde (19.73 mmol) was dissolved in 50 mL of toluene and cooled to 0° C. Diphenylphosphoryl azide (29.6 mmol, 1.5 eq) was added, followed by 1,8-diazabicyclo[5.4.0]undec-7-ene (23.07 mmol, 1.2eq). After stirring at room temperature overnight, the solvent was evaporated. The residue was purified by SiO2 chromatography (5-30% ethyl acetate in dichloromethane) to afford the title compound. MS (m/z): 204.2 (M+H).

1. customthe solvent was evaporated
2. customThe residue was purified by SiO2 chromatography (5-30% ethyl acetate in dichloromethane)