HCID 86604864, compound → HCID 86760972, compound

HRID 1432007Notes

Reaction equation

HRID 1432007 reaction equation
C1(S(N2CCNC(=O)[C@H]2CC#C)(=O)=O)C=CC=CC=1.[O:20]([C:22]1[CH:27]=[CH:26][C:25]([S:28]([N:31]2[CH:36]=[CH:35][NH:34][C:33](=[O:37])[C@H:32]2[CH2:38][C:39]#[CH:40])(=[O:30])=[O:29])=[CH:24][CH:23]=1)[CH3:21]>>[O:20]([C:22]1[CH:23]=[CH:24][C:25]([S:28]([N:31]2[CH2:36][CH2:35][NH:34][C:33](=[O:37])[C@H:32]2[CH2:38][C:39]#[CH:40])(=[O:30])=[O:29])=[CH:26][CH:27]=1)[CH3:21]

Participants

3

Reactant 2

HCID 86604864HCID 86604864, compoundHCID 86604869HCID 86604869, compound

Product 1

HCID 86760972HCID 86760972, compound

Procedure

Using the procedure described for compound 51, (R)-4-(4-methoxylbenzenesulfonyl)-3-(prop-2-ynyl)-3,4-dihydropyrazin-2(1H)-one afforded the title compound as a tan solid. 1H NMR (300 MHz, DMSO-d6): δ 2.65 (m, 1H), 2.86 (m, 2H), 2.90 (s, 1H), 3.05 (m, 1H), 3.61 (m, 2H), 3.87 (s, 3H), 4.25 (t, 5.4 Hz, 1H), 7.08 (d, 8.3 Hz, 2H), 7.81 (d, 8.3 Hz, 2H), 8.06 (s, 1H).

Sources & evidence

ORD record
ord-f90047e784d24e3c82abe6734095baf0
Source dataset
uspto-grants-2009_11
Patent number
US07612060B2

Reaction notes

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