Bromine → HCID 58962998, compound

HRID 1432070Notes

Reaction equation

HRID 1432070 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[NH:10][CH2:11][CH2:12][CH3:13])[C:5]#[N:6].[Br:14]Br>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Br:14])[C:9]=1[NH:10][CH2:11][CH2:12][CH3:13])[C:5]#[N:6]

Participants

4

Reactant 2

HCID 24408BromineHCID 58962941HCID 58962941, compound

Product 1

HCID 58962998HCID 58962998, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Step AR2. To 3-chloro-4-(propylamino)benzonitrile (365 mg, 1.87 mmol) in MeOH (10 ml) was added bromine (300 mg, 1.87 mmol) in MeOH (2 mL) dropwise. After stirred for 30 minutes, the solvent was removed and crude 3-chloro-5-bromo-4-(propylamino)-benzonitrile was obtained (549 mg, 100%).

Workup

  1. customthe solvent was removed

Sources & evidence

ORD record
ord-a02694901be1414fb64f5d685f378024
Source dataset
uspto-grants-2009_11
Patent number
US07612069B2

Reaction notes

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